The core issue for future medical developments has been understanding not just the effects, but the processes that lead to them within the body. Resveratrol actually activates proteins called sirtuins in the body.

These proteins are gaining a somewhat mythical reputation, as they have been found to powerfully stave off many health problems, including diabetes, once they are switched on and pointed in the right direction. Therein lies the trick, with the targeting of sirtuins and the proper activation of them.

For diabetes, there is a particular class of sirtuins located in the brain that control and monitor glucose metabolism, a key issue with diabetes. Therefore researchers at the University of Texas Southwest Medical Center delivered resveratrol directly to the brains of mice. The targeted sirtuins were activated, and diabetic symptoms were improved, reducing high blood sugar and insulin levels.

This is a groundbreaking discovery, because it specifically shows the cause and effect process of resveratrol on a specific health problem, rather than just looking at the end result. Therefore instead of taking an all encompassing supplement, drugs can be developed in the future that specifically target sirtuins in the brain for Type 2 Diabetes patients, and those predisposed to the disease.

It also means that more specific work will be done to see which sitruins are activated by resveratrol to cause which effects. It’s a huge step to creating effective, reliable and safe resveratrol drugs that can combat some of the worst health problems on the planet. Thanks to this research at the University of Texas Southwest Medical Center, a resveratrol based medication for diabetes that targets sirtuins in the brain is now a real possibility.

It’s clear now though that he’s not the only person supporting those claims, and now many new companies are beginning to develop drugs and products that could offer a huge array of health benefits, including the highly sought after life extension principles that earlier work on insects and animals showed.

The key to the benefits provided by resveratrol may be sitruin activators in the body. Resveratrol activates sirtuins, which are a specific type of protein in the body. These proteins are believed to help the body cleanse itself from toxins. This means that they can help prevent diseases, they can boost the immune system and they can even help to extend the healthy life of a person.

This extension of life is mostly caused by the prevention of major ailments and disruptions. When mice are placed on a caloric restriction diet, eating approximately 30 percent less calories, then they experience an increase in life expectancy of about 40 percent. Activating sirtuins within the body is thought to be able to provide these same benefits, to the same degree or potentially even stronger.

What kinds of diseases can be combated, and what kinds of benefits can be offered? Running down the list, you’ll see that you’ll find the majority of deadly diseases that plague the world’s otherwise healthy population. This includes diabetes, cardiovascular disease, several types of cancer including colon and lung, Alzheimer’s and more, all of which can be potentially fought off or prevented through sirtuin activation.

Sirtris Pharmaceuticals, named for sirtuins, is in the process of developing clinical drugs that can help activate sitruins and provide all of these great benefits in a safe, consistent matter. They don’t make use of resveratrol itself, but rather they make use of drugs that copy the effects of the compound within the human body.

The compounds they have developed are even stronger and more potent than resveratrol itself, which means they can be administered in smaller, more manageable doses. It also means that the benefits could be even more far reaching than what science has thus far found.

Sirtris Pharaceuticals is testing many of their new drugs and compounds in clinical trials already. Some of their compounds include SRT-501, SRT-2104 and SRT-1720, all of which are chemical impersonators of resveratrol.

Their SRT-501 compound is being put up against colon cancer and multiple myeloma; SRT-2104 is in trials for Type 2 diabetes and SRT-1720 has already been found to increase healthy life expectancy in mice. So far, as results are coming to come in as being successful, there has also been a healthy lack of side effects, meaning the research and trails are both continuing to more advanced degrees.

So how is all of this really possible? What is it about sitruin activators that can help to slow, reverse or stall the aging process? Researchers now view many aging related ailments and changes as the inevitable result of ongoing DNA mutations as you grow older. However, Dr. Sinclair actually points to these mutations changing or removing the presence of sirtuins. Therefore by combating this problem, and working on sirtuin activation in the right ways at the right time, aging can actually be reversed or stopped.

Sirtris Pharamaceuticals is one of many companies and researchers that are optimistic about this and similar potential benefits. Sirtris has a goal of putting out to the market legitimate longevity drugs within five years. With the research they have thus far backing their claims, that seems to be a strong possibility. Of course, drug development and trials are no sure thing, and early results from effectiveness trials won’t be available for at least another year.

Until then, everyone looking for the next miracle drug will have to wait. Research clearly shows that resveratrol, through sirtuin activation, can provide a slew of healthy benefits. Now, can those benefits be harnessed into a clinically proven drug for the masses?

The strongest aspect of this booklet from Parente is its size, length and style. It’s a condensed 40 pages, and it crams a lot of solid information and research into that space. With its short length, you will be able to pick the book up and read right through it, learning as you go and never becoming overwhelmed.

You won’t have to worry about trying to read all of the latest reports and studies, or worry about embarking on a long journey with volumes of literature and text. In just 40 pages the Resveratrol booklet manages to sum up all of the important, relevant research on the subject.

Best of all, the book doesn’t try to be pretentious about what it is saying or what it provides. That means all of the medical and scientific jargon has been weeded out, so that anybody can fully understand all of the points that are being made.

So why did Matilde Parente release this informational packet? For one thing, she is a wine enthusiast who was highly intrigued about resveratrol and its health benefits, particularly aspects such as the highly publicized French Paradox. Additionally, she’s a physician, medical consultant and public speaker, and has the experience, knowledge and background to apply the available literature and science to real life.

The result is a quick, surprisingly fun read that explains everything you need to know about resveratrol and its benefits. Are the benefits legitimate according to Parente? Well, yes. Everything from acting as a deterrent for Alzheimer’s to preventing the formation of blood clots, acting as a powerful antioxidant and much more. Maybe it’s not the cure-all or miracle drug that some manufacturers try to sell it as, but it is certainly a powerful, health boosting tool.

If you’re unsure of what to make of all of the latest resveratrol news, then pick up a copy of this informational booklet from Matilde Parente. It’s a quick, light (and cheap) read that easily explains the vast amount of information and research on resveratrol, and applies all of it to how it can benefit you.

As a consequence of the negative press, it has turned into a bit of a buzz kill for the legitimate producers of resveratrol supplements, that offer “pay for” products that often have solid research and proprietary formula behind their offerings. Sales have taken a drop for many of these resveratrol companies that have informative websites with clear contact details and return policies – not just a hyped up sales page with a lot of fine print.

The point to observe is that sharlatans and unethical opportunists always jump on the bandwagon to capture media driven interest initially to make short term profits. It emphasizes that a true interest and market for real products, that are manufactured under quality controlled conditions and even backed by independent labs and doctors/researchers, exists and will continue to thrive in the future.

Because of the inertia created by the voluminous research that is so compelling, scientists from a plethora of backgrounds are researching the attributes of this multi-faceted molecule and its health benefits. Consumers have been given quite a bit to doubt lately, because of the firestorm and backlash against unscrupulous marketers, but the ongoing studies and results of the efficacious properties that seem to be present in resveratrol should give any person, seriously interested in longevity and overall health, pause.

There is certainly more evidence pointing to resveratrol being a naturally beneficial molecule across a diverse landscape of human ailments, than skeptical criticisms warning people to be conservative or ask their physician? Many doctors are not even aware of resveratrol still, and if you haven’t noticed, many are not the healthiest creatures on the planet either! You should trust your own instincts and do your own reading about the potential benefits and make your own decision to try a legitimate resveratrol product.

If in doubt, buy a bottle or package from an established website that sells their own brand or other reputable brands. Remember – you get what you pay for …. so the free trials with the $89/recurring billing is definitely going to be more expensive and more aggravating judging from the comments left on this blog and others recently.