Resveratrol

Experiments dating back to the 1930s, conducted by Dr. Clive McKay at Cornell University, have shown that feeding laboratory animals about a third fewer calories than they would eat freely, without causing malnutrition, can dramatically increase their longevity.

Mice in this situation have lived four years longer than normal, a 40 percent increase. Moreover, they remain much healthier than their freely eating counterparts, showing an equally dramatic delay in the onset of age related diseases including a reduced incidence of diabetes, heart disease, cancer and other ailments.

The McKay trial has been replicated thousands of times with many other species including monkeys and dogs with the results continuing to demonstrate a significant correlation between calorie intake and lifespan.

CALORIE RESTRICTION IN DOGS

In May of 2002, the results of the experiment regarding caloric restriction on dogs were published in JAVMA (Journal of American Veterinary Medical Association).

The objective of the trial was to evaluate the effects of diet restriction on the lifespan and on markers of aging. 48 Labrador Retrievers were paired up and one dog in each pair was fed 25% less food than its pair-mate from 8 weeks of age until death.

The results showed that “compared to the control dogs, the food restricted dogs weighed less and had lower body fat content and lower serum triglycerides, triiodothyronine, insulin, and glucose concentrations. Median lifespan was significantly longer for dogs in which food was restricted. The onset of clinical signs of chronic disease generally was delayed for the food restriced dogs.”

RESVERATROL IS PROVEN TO MIMIC CALORIE RESTRICTION

The many health benefits associated with resveratrol have long been attributed to its ability to mimic the effects of a calorie restrictive diet. Research published in the June 3 issue of the online, open-access journal Public Library of Science One (PLoS One) established it as fact reporting the “striking transcriptional overlap of caloric restriction (CR) and resveratrol”

A team of international researchers found that low doses of resveratrol slowed the aging process in middle-aged mice and improved their overall heart health. Specifically, the results observed in the resveratrol-fed mice mimicked those often seen with caloric restriction — the practice of cutting 20%-30% of calories out of one’s typical diet in an effort to improve health and prolong life. Numerous studies have linked caloric restriction to a longer, healthier life.
What’s more, the study researchers discovered that resveratrol is active in much lower doses than previously thought. Until now, researchers believed that high doses of resveratrol — impossible to obtain by drinking wine — were necessary to ward off the unhealthy consequences of eating a high-fat, high-calorie diet.
“This brings down the dose of resveratrol toward the consumption reality mode,” study researcher Richard Weindruch, a University of Wisconsin-Madison professor of medicine and a researcher at the William S. Middleton Memorial Veterans Hospital, says in a news release.
The researchers believe their findings provide strong evidence that resveratrol can improve one’s quality of life and call the idea of low-dose resveratrol supplementation “a robust intervention in the retardation of cardiac aging.”

RESVANTAGE Brand Resveratrol offers a low dose resveratrol supplement for dogs and cats now.

The makers of RESVANTAGE, a resveratrol supplement company have expanded their offerings to include a resveratrol supplement for dogs and cats so that these animals can enjoy the health benefits of a caloric restrictive diet without their owners having to actually restrict their diets. It’s a viable way to tap into the science of CR and its positive effects on healthy aging while avoiding the resultant loss in body weight of the animal and potential loss of nutrients that a CR diet might cause.

In November 2002, The National Cancer Institute wrote: a powerful anti-oxidant and anti-inflammatory, “resveratrol may be an effective chemopreventive agent in three stages of the cancer process: initiation promotion and progression.”

Resvantage Canine and Feline is for both healthy pets as well as for dogs and cats with health issues such as diabetes, cancer, cardiovascular problems, fatty liver disease, hip displaysia, cognitive declines and other afflictions common with aging. There are numerous clinical trials showing the efficacy of resveratrol in lowering insulin resistance, reducing tumor incidence, breaking down fat in the liver, relieving the symptoms of arthritis and demonstrating it’s neuro protective action.