Resveratrol – Diabetes

Resveratrol, the molecule found in grapes (and the red wine produced from them) and certain other plants, is actively being tested in research laboratories around the world in hopes to find both prevention and relief for illnesses such as cancer and heart disease. Clinical trials of resveratrol are also currently under way to combat other diseases, including diabetes.

In late 1999, research was published of a study that showed that type 2 diabetic participants that drank two five-ounce glasses of red wine with their meal experienced lowered incidences of the production of compounds that can produce vascular damage, an interesting result to say the least for those studying diabetes. More recently, studies on mice have shown that even low levels of resveratrol doses can improve their sensitivity to hormone insulin. The findings could lead to the development of new therapies for both prevention and treatment of type 2 diabetes. Continuing research will hopefully tell if resveratrol might have further benefits for not only type 2 diabetes and diabetic vascular disease, but other insulin disorders as well.

Resveratrol is known to activate a gene called SIRT1, and SIRT1 is linked not only to insulin secretion, but also to better insulin sensitivity in mice. Other research has found a connection between SIRT1 and glucose metabolism. Researchers have reported that insulin resistant disorders like diabetes block normal activation of SIRT1, a factor resulting in the active study of SIRT1 activating compounds, of which resveratrol in certainly a front runner.

Ongoing investigation is required before resveratrol supplementation can be responsibly approved for diabetes disorders, but early findings have given enough initial positive results to warrant further research for scientists and medical researchers alike.

5 comments to Resveratrol – Diabetes

  • I’m taking 100mg of high quality reservatrol every day. Would you say this is a good dose for a long period of time. I have diabetes and high blood pressure. I’m also taking my regular prescription drugs with this supplement. Would adding reservatrol help me in the long run. Thanks

  • admin

    I have read that resveratrol only last about 9-12 hours in the body – or at least that is the time it activates the proteins in the cell’s DNA that provides the benefits. Therefore, it was suggested to take every 12 hours to activate the sirt 1 gene 24/7. The dosage depends on the bioavailability of the resveratrol – powders and tablets are less effective apparently than capsules with liquid formula – especially those manufactured in an oxygen free enviroment. You may want to consider a lower dose resveratrol supplement that you can take twice a day without concern for any side effects.

  • Valerie Sykes

    I have the same concerns as Bruce above, same condition. I’m taking the Resveratrol 100 mg and a couple of days ago I find out I have Diabetes Type 2.

    What side affects should I look for? Also, can I continue to use every day? I take one in the morning and one middle afternoon.

    Is there additional information I should know about? Would appreciate your response.


  • the best way to manage diabetes is through Diet and Exercise. Food supplements like Alpha Lipoic acid helps in preventing nerve damage while Chromium helps in the regulation of blood sugar.

  • Al T

    I have diabetes and in August my blood level was a 8.1, I started taking reservatrol 500 mg twice a day with 2400 mg of fish oil. my blood level just was taken and it dropped to 7.4. another thing I noticed is that I had a deep cut from work, it healed in a short time. and a scar I had has been noticibly lighter. So all in all I do see results, and will continue to use it.

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